Hormone Therapy in Prostate Cancer
In most cases, prostate cancer is a hormone-dependent tumor, particularly androgens. When androgens are removed from the blood is the improvement of the symptoms caused by metastases or urinary obstruction, and, lower PSA levels.
It is a palliative treatment, achieving the improvement of symptoms in patients with advanced disease (metastases), the delay of clinical progression and possibly prolonging surviva
Androgens are produced mostly (90-95%) in the testes in the form of testosterone, and the remainder (5-10%) in the adrenal glands, which lie on top of both kidneys. These act on the prostate androgen stimulating the proliferation of tumor cells
Androgen suppression will be achieved through drug therapy (medication) or surgical treatment by removing the testes or testosterone-producing tissue (orchiectomy).
Generally, involves excision of the inside of the testicle, where the testosterone-producing tissue. It is a simple operation requiring anesthesia and brief hospitalization that generally does not exceed 24 hours. Postoperative recovery to normal life is fast and hardly any complications.
Hormonal effects of orchidectomy derivatives are immediate, resulting in a decrease of testosterone within 24 hours. This treatment is not reversible, generating a final withdrawal of testosterone.